FOIA Eur J Cardiothorac Surg. }v~/lceM-. A loading regimen (i.e., use of a relatively high dosage at the beginning of therapy) can shorten the delay. Even in patients at high risk of arrhythmic death, in whom the toxicity of this drug is an acceptable risk, this drug poses major management problems that could be life-threatening in a population at risk of sudden death, so that every effort should be made to utilize alternative agents first. Stopping the infusion and restarting at a slower rate may help if infusion-related reactions occur. Ocular: Ophthalmic examination, including fundoscopy and slit-lamp examination, Respiratory: History, physical exam, chest X-ray, and pulmonary function tests, including diffusion capacity. Renal Dosing: crcl 10-50 ml/minute: Administer every 6-12 hours. Approved for acute termination. After the first 24 hours, the maintenance infusion rate of 0.5 mg/min (720 mg/24 hours) should be continued utilizing a concentration of 1 to 6 mg/mL (Cordarone I.V. 1 0 obj Supplied: 50 mg, 100 mg, 150 mg tablet. Amiodarone is a potent antiarrhythmic agent that is used to treat ventricular arrhythmias and atrial fibrillation. Adverse reactions: Severe hypotension; bradycardia; ventricular standstill in digitalized patients; asystole; respiratory failure. Oral: 250-500 mg/dose every 3-6 hours or 500 mg to 1 g every 6 hours extended release; usual dose: 50 mg/kg/24 hours; maximum: 4 g/24 hours. 4 0 obj concentrations greater than 2 mg/mL should be administered via a central venous catheter). Use Alaris LVP with Guardrails and select amIODAROne LOAD - = 60 kg in Critical Care Adult or Coronary Care Unit profile. dose. Atrial Fibrillation (AF) & Flutter complicating critical illness Injection: 80 mg/ml (10 ml) (gluconate). Dosing (adults): Ventricular arrhythmias: Oral: 1200-1800 mg/day in 3 divided doses, up to 2400 mg/day. Infusion rate: 318 mL/hr. Patients who received intravenous amiodarone for less than one week should take 800 to 1,600 mg oral amiodarone per day.2 Patients who received intravenous amiodarone for one to three weeks should take 600 to 800 oral amiodarone per day, and patients who received intravenous amiodarone for more than three weeks should take 400 mg oral amiodarone per day. IV to oral transition (infusion duration Prescribe as per one of the following schedules depending on clinical urgency and Unauthorized use of these marks is strictly prohibited. Hypotension necessitating alterations in intravenous amiodarone therapy was reported in 3% of patients, with permanent discontinuation required in less than 2% of patients. The dosage of amiodarone should be kept at the lowest effective level. Obtain a baseline chest X-ray and pulmonary-function tests, including diffusion capacity, when treatment with this drug is initiated. Infusion: 1 to 3 weeks Initial Daily Dose of Oral Cordarone : 600-800 mg. Intravenous The authors report no conflicts of interest. (Enter numeric value only. Age, sex, renal disease, and hepatic disease (cirrhosis) do not have marked effects on the disposition of amiodarone or DEA. Although the frequency of such proarrhythmic events does not appear greater with this drug than with many other agents used in this population, the effects are prolonged when they occur. DOSE RECOMMENDATIONS -- FIRST 24 HOURS -- Loading infusions. Factors that increase likelihood of digoxin toxicity: Hypokalemia, hypomagnesaemia, hypothyroidism, renal dysfunction, interacting drugs (eg quinidine, verapamil). Cordarone IV Use carton to protect contents from light until used. From in vitro studies, the protein binding of amiodarone is >96%. Maintenance dose should be determined according to antiarrhythmic effect as assessed by patient tolerance as well as symptoms, Holter recordings, and/or programmed electrical stimulation; some patients may require up to 600 mg/day while some can be controlled on lower doses. Amiodarone Hydrochloride Injection, 50 mg/mL is supplied in: IV to PO amiodarone This site needs JavaScript to work properly. Pulmonary toxicity has been fatal about 10% of the time. Intravenously administered amiodarone causes heart block or bradycardia in 4.9 percent of patients and hypotension in 16 percent.2 If these conditions occur, infusion of the drug should be discontinued, or the rate of infusion should be reduced. INDICATIONS AND USAGE: SOTYLIZE is an antiarrhythmic indicated for: The treatment of life-threatening ventricular arrhythmias. Monitor BUN and serum creatinine q2days (qd if unstable). (Doses <0.5 mg have been associated with paradoxical bradycardia.). (150 mg) to 100 mL D5W. Cardiac Arrest: First dose: Give 300 mg (6 mL) IV direct UNDILUTED. Adverse reactions: dose related hypotension; ventricular arrhythmias; heart failure. Would you like email updates of new search results? If the starting dose was 125 mcg twice daily, then adjust to 125 mcg every day. Drugs for Conversion of Atrial Fibrillation | AAFP Bronchospasm: 0.1-0.5 mg IM, SQ (1:1000): every 10-15 minutes to 4 hours. Bethesda, MD 20894, Web Policies Use of these drugs would be most appropriate in patients with recurrent hemodynamically unstable atrial fibrillation.10 Amiodarone may be particularly beneficial in patients with rapid ventricular rates or impaired renal function. Crcl 30-60 ml/min: Administer every 24 hours. Frendl G, Sodickson AC, Chung MK, et al. 2011;92:11441152. Storage requirements: The manufacturer product information should be consulted. Amiodarone administered orally or intravenously - the is about 1000 mg over the first 24 hours of therapy, delivered by the following infusion regimen: First Rapid: 150 mg Supplied: 0.02 mg/ml (10 ml); 0.2 mg/ml (1:5000) (1 ml, 5 ml). Amiodarone has been associated with toxicity involving the lungs, thyroid gland, liver, eyes, skin, and nerves (Table 2).2,5,11,19 The frequency of most adverse effects is related to the total amiodarone exposure (i.e., dosage and duration of treatment). We comply with the HONcode standard for trustworthy health information. Thyroid toxicity is the most common complication that requires intervention. Onset of action: 2-10 minutes. The patient is obviously at great risk during this time and may need prolonged hospitalization. Amiodarone: I.V. Assistance in calculating accurate rates of medication administration. Supplied: 150 mg, 200 mg, 250 mg capsule. Intraoperative tachycardia and/or hypertension (immediate control): Initial bolus: 80 mg IV (~1 mg/kg) over 30 seconds, followed by a 150 mcg/kg/minute infusion, if necessary. Renal Dosing: CRCL >60 ml/min: Administer 500 mcg twice daily. Like class I drugs, amiodarone blocks sodium channels at rapid pacing frequencies, and like class II drugs, it exerts a noncompetitive antisympathetic action. Drugs for Conversion of Atrial Fibrillation | AAFP Attempts to substitute other antiarrhythmic agents when this drug must be stopped will be made difficult by the gradually, but unpredictably, changing body burden of this drug. Although the U.S. Food and Drug Administration (FDA) has labeled amiodarone only for the treatment of life-threatening ventricular arrhythmias, the drug also is used to treat atrial fibrillation. Amiodarone To comment please, Comments on Medscape are moderated and should be professional in tone and on topic. Studies on the use of amiodarone for the primary prevention of sudden death in high-risk patients have had mixed results. Hepatic impairment: Reduce dose by 50%. Effective in @30% of patients. [Oral bioavailability (tablets): 70 to 80%]. If progressive hepatic injury or hepatomegaly occurs or hepatic enzyme levels increase to greater than 3 times normal (or double in a patient with elevated baseline levels): Consider dose reduction or discontinuation. Use of evacuated glass containers for admixing Cordarone I.V. WebA client is receiving an IV solution of sodium chloride 0.9% (Normal Saline) 250 ml with amiodarone (Cordarone) 1 gram at 17 ml/hour. Amiodarone 150 mg/3 ml Concentrate for Solution for Injection/Infusion Active Ingredient: amiodarone hydrochloride Company: Bowmed Ibisqus Limited See contact details About Medicine Prescription only medicine Healthcare Professionals (SmPC) Patient Leaflet (PIL) This information is for use by healthcare professionals The elimination half-life of amiodarone is highly variable and unusually long, averaging about 58 days. In the event of breakthrough episodes of VF or hemodynamically unstable VT, Give 150-mg/100 ml D5W over 10 minutes to minimize potential for hypotension. <> endobj Routine screening for adult respiratory distress syndrome is of limited value, because pulmonary toxicity can develop rapidly with no antecedent abnormalities on chest radiographs or pulmonary function tests. J Am Coll Cardiol. Initial Daily Dose of Oral Cordarone 1 week 800-1600 mg 1-3 weeks 600-800 mg >3 weeks* 400 mg # Assuming a 720 mg/day infusion (0.5 mg/min). * Cordarone I.V. is not intended for maintenance treatment. HOW SUPPLIED Cordarone I.V. (amiodarone HCl) is available in packages of 10 ampuls (2 cartons each containing 5 ampuls), 3 mL each, as follows: Crcl 10-30 ml/min: Administer every 36-48 hours. government site. Half-life: 38-48 hrs. The maintenance infusion of up to 0.5 mg/min can be cautiously continued for 2 to 3 weeks regardless of the patient's age, renal function, or Left-ventricular function. /QU+(R% $Kh=c6cL`bv!w? Bradycardia and heart block occur in 1 to 3 percent of patients receiving amiodarone.2 Amiodarone-induced proarrhythmia occurs at an annual rate of less than 1 percent.11 Although almost all patients treated with the drug have prolongation of the QT interval, polymorphic ventricular tachycardia (i.e., torsades de pointes) is rare. IV: Therefore, all patients should be cautioned to use sunblock and, whenever possible, to cover exposed skin when they are outdoors. Amiodarone Intravenous N-desethylamiodarone (DEA) is the major active metabolite of amiodarone in humans. If liver enzyme levels are three times higher than normal, amiodarone should be discontinued unless a patient is at high risk for recurrence of life-threatening arrhythmia.2. Amiodarone may subsequently be continued until the patient has recovered from their critical illness (e.g., for 1-2 weeks). Major adverse reactions: proarrhythmic events: VT, PVC's, BC, AV block, torsades de pointes, etc. Drip preparation: Add 2.5 grams/ 250 ml D5W or NS [Drip rate (ml/hr)= wt(kg) x mcg/min x 0.006 ]. Time to steady state: 5-7 days (average) ESRD: 15-20 days. based on a 1:2.5 conversion from IV to PO: = Link to online calculator. This site complies with the HONcode standard for trust- worthy health information: verify here. PROARRHYTHMIC EFFECTS: Like other antiarrhythmics, this drug can exacerbate the arrhythmia, e.g., by making the arrhythmia less well tolerated or more difficult to reverse. Sotalol does not have partial agonist or membrane stabilizing activity. Heart Views. (loading dose only): 2 to 2.5 times the IV dose. Web[IV route] Dose: 150 mg IV x1 over 10min, then 1 mg/min IV x6h, then 0.5 mg/min IV x18h [PO route] Dose: 400 mg PO qd; Start: load 800-1600 mg PO qd x1-3wk until response, then Pacerone, Cordarone (amiodarone) dosing, indications, interactions Hepatic impairment: Maximum daily dose: 1200 mg. infusions exceeding 2 hours must be administered in glass or polyolefin bottles containing D5W. Any patient who notes changes in visual acuity or peripheral vision should be referred for ophthalmologic evaluation. Cordarone IV is a prescription medicine used to treat the symptoms of irregular heart rhythm (Ventricular Arrhythmias). Continued monitoring for doses 2-5: QTc interval must be determined 2-3 hours after each subsequent dose of dofetilide for in-hospital doses 2-5. Disclaimer. 1.Desired Dose. Our study suggests following conversion to normal sinus rhythm; cardiothoracic surgery patients can effectively and safely be transitioned from IV to oral amiodarone without the need for specific overlap duration or transition strategy. The maintenance infusion of up to 0.5 mg/min can be cautiously continued for 2 to 3 weeks regardless of the patient's age, renal function, or Left-ventricular function. UpToDate Photosensitivity is common in patients receiving amiodarone therapy. What should we do for this patient? Peak concentrations after 10-minute infusions of 150 mg intravenous amiodarone in patients with ventricular fibrillation (VF) or hemodynamically unstable ventricular tachycardia (VT) range between 7 and 26 mg/L. David McAuley, Pharm.D. If severe, stop amiodarone or insert pacemaker. Intravenous amiodarone therapy should not be used in patients with bradycardia or heart block who do not have a pacemaker. Mechanism of Action Adenosine is a potent vasodilator in most vascular beds, except in renal afferent arterioles and hepatic veins where it produces vasoconstriction. Hypotension, bradycardia, atrioventricular block. Copyright 2003 by the American Academy of Family Physicians. If intravenous amiodarone is administered during pregnancy, the patient should be apprised of the potential hazard to the fetus. Amiodarone (Cordorone) IV to Oral conversion loading and The drug's high iodine content likely is a factor in its effects on the thyroid gland. F~GMlILIvau88}]nv9W_%o"v2=Wo- hh Hypotension (refractory to dopamine/dobutamine): Initial (continuous infusion): 1 mcg/minute (range: 1-10 mcg/minute); titrate to desired effect; severe cardiac dysfunction may require doses >10 mcg/minute (up to 0.1 mcg/kg/minute). Each milliliter of the Cordarone I.V. Monitoring: Pacerone, Cordarone, Nexterone, Cordarone IV. All material on this website is protected by copyright, Copyright 1994-2023 by WebMD LLC. formulation contains 50 mg of amiodarone HCl, 20.2 mg of benzyl alcohol, 100 mg of polysorbate 80, and water for injection. 150 mg, 225 mg, 300 mg tablet. The site is secure. See labeling for oral amiodarone. The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical judgment. CLINICAL PHARMACOLOGY After intravenous injection of Digoxin Immune Fab (Ovine) in the baboon, digoxin-specific Fab fragments are excreted in the urine with a biological half-life of about 9 to 13 hours.1 In humans with normal renal function, the half-life appears to be 15 to 20 hours.2 Experimental studies in animals indicate that these antibody fragments have a large volume of distribution in the extracellular space, unlike whole antibody which distributes in a space only about twice the plasma volume.1 Ordinarily, following administration of DIGIBIND, improvement in signs and symptoms of digitalis intoxication begins within one-half hour or less.2,3,4,5. Bookshelf INDICATIONS AND USAGE MULTAQ is indicated to reduce the risk of cardiovascular hospitalization in patients with paroxysmal or persistent atrial fibrillation (AF) or atrial flutter (AFL), with a recent episode of AF/AFL and associated cardiovascular risk factors (i.e., age >70, hypertension, diabetes, prior cerebrovascular accident, left atrial diameter 50 mm or left ventricular ejection fraction [LVEF] <40%), who are in sinus rhythm or who will be cardioverted. Amiodarone: Clinical uses - UpToDate INFUSION Duration of Cordarone I.V. Thyroid abnormalities have been described in up to 10 percent of patients receiving long-term amiodarone therapy.2 Hyperthyroidism may result from an excess of iodine or acute thyroiditis.20 Hypothyroidism is two to four times more common than hyperthyroidism.2, In hypothyroid patients with a strong clinical indication for amiodarone, the drug may be continued with appropriate thyroid hormone supplementation. [900 mg / 500 ml ] [See comments] This dose can be used in patients in acute distress or when a serum concentration is not available. May repeat x 1 in 10 minutes if needed. This may be calculated if the amount ingested is known or the postdistribution serum drug level is known (round dose to the nearest whole vial). High-resolution computed tomographic scanning can be helpful in making a diagnosis. Also, an in-line filter should be used during administration. A naive look at this scenario gives the impression that the patient has not been started on an oral loading dose of amiodarone. Thallium-201 is injected at midpoint (3 minutes) of infusion. IV to oral transition (infusion duration [assuming 0.5 mg/min infusion]: initial oral daily dose). WebThis calculator is not appropriate for the following patient populations: Significant drug interactions (eg, amiodarone, quinidine, verapamil, or macrolide antibiotics) End-stage The systemic availability of oral amiodarone in healthy subjects ranges between 33% and 65%. See table. Serum levels: 0.5 to 2.0 ng/ml. In patients with severe left ventricular dysfunction, the pharmacokinetics of amiodarone are not significantly altered but the terminal disposition t1/2 of DEA is prolonged. Congestive heart failure can mimic amiodarone pneumonitis and, thus, must be ruled out early in the evaluation. This article reviews the pharmacology, indications, adverse effects, and drug interactions of amiodarone, and outlines a strategy for surveillance of patients who are taking this drug. > 3 weeks. Optic neuropathy and optic neuritis, sometimes progressing to total blindness, have been described in a small number of patients treated with amiodarone. Adenosine may also lessen vascular tone by modulating sympathetic neurotransmission. Although significant beta-blockade occurs at oral doses as low as 25 mg, significant Class III effects are seen only at daily doses of 160 mg and above. IV compatibility: The manufacturer product information should be consulted. Please review the latest applicable package insert for additional information and possible updates. Mechanism of Action: Sotalol has both beta-adrenoreceptor blocking (Vaughan Williams Class II) and cardiac action potential duration prolongation (Vaughan Williams Class III) antiarrhythmic properties. Laboratory studies to assess liver and thyroid function should be performed at least every six months. (150 mg) to 100 ml D 5 W. Infuse 100 ml over 10 minutes. Medscape Pharmacists. May be administered once a day; twice a day dosing is recommended for total daily doses of 1000 mg or more or in patients who experience gastrointestinal tolerance. This can be followed by a CRI (1020 mcg/kg/min). Renal Dosing Ventricular arrhythmias (Betapace): Crcl >60 ml/min: Administer every 12 hours. Interactions with warfarin and digoxin are the most clinically important. However, the drug has many other effects: it slows heart rate and atrioventricular nodal conduction (via calcium channel and beta-receptor blockade), prolongs refractoriness (via potassium and sodium channel blockade), and slows intracardiac conduction (via sodium channel blockade). 2010;55:13701376. WebWhen appropriate, monitor and adjust IV dose as necessary. Patients with a known predisposition to bradycardia or AV block should be treated with intravenous amiodarone in a setting where a temporary pacemaker is available. Consider stopping amiodarone; causal relationship is uncertain. In the event of breakthrough episodes of VF or hemodynamically unstable VT, Give 150-mg/100 ml D5W over 10 minutes to minimize potential for hypotension. Hypotension Ingestion of more than 10 mg of digoxin in previously healthy adults or 4 mg of digoxin in previously healthy children, or ingestion causing steady-state serum concentrations greater than 10 ng/mL, often results in cardiac arrest. Copyright 2022 Wolters Kluwer Health, Inc. All rights reserved. The only information that I could find about PO to IV conversion involved patients who are stabilized on amiodarone PO for 4 months or longer. Amiodarone is metabolized to desethylamiodarone by the cytochrome P450 (CYP450) enzyme group, specifically cytochrome P450 3A4 (CYP3A4) and CYP2C8. Accessibility Restated: Duration of IV infusion < 1 week: 800-1600mg/day po initially x 1-2 weeks or complete current week; 1-3 weeks: 600-800mg/day po initially - total therapy ~ 1 month counting IV infusion ; >3 weeks: 400mg po qd initially. If the starting dose was 250 mcg twice daily, then adjust to 125 mcg twice daily. There is limited experience in patients receiving Cordarone I.V. (Must use 0.22 micron filter) Improvement in signs and symptoms usually begins in 30 minutes or less.Stability: Use promptly after mixing (may refrigerate up to 4 hours). Followed by Slow: 360 mg over the NEXT 6 hours (1 mg/min). Steady-state amiodarone concentrations of 1 to 2.5 mg/L have been associated with antiarrhythmic effects and acceptable toxicity following chronic oral amiodarone therapy. However, recent studies have shown that aggressive attempts to maintain sinus rhythm using amiodarone or other drugs do not improve outcomes in relatively asymptomatic patients.13,14 Therefore, long-term amiodarone therapy, with its potential for toxicity, does not appear to be justified in patients who are taking anticoagulant drugs if rate-control strategies can provide satisfactory symptomatic improvement. Neither GlobalRPh Inc. nor any other party involved in the preparation of this program shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material. All Rights Reserved. The objective of this study was to evaluate the safety and efficacy of varying durations of overlap when amiodarone IV infusion is transitioned to oral administration in cardiothoracic surgery patients. HEPATOTOXICITY: Liver injury is common with this drug, but is usually mild and evidenced only by abnormal liver enzymes. The primary outcome was AF recurrence within 24 hours after IV amiodarone discontinuation. AF recurrence occurred in 24.5% of patients (n = 45). Copyright 1993-2021 endobj If side effects become excessive, the dose should be reduced. WebAmiodarone shows beta blocker-like and calcium channel blocker-like actions on the SA and AV nodes, increases the refractory period via sodium- and potassium-channel effects, and slows intra-cardiac conduction of the cardiac action potential, via sodium-channel effects. Dosage for toxicity during chronic therapy : for adults, 6 vials (228mg) usually is adequate to reverse most cases of toxicity. 2004;4(1)2004Medscape. Obtain first level within 24 hours of digitalization. Do Not Copy, Distribute or otherwise Disseminate without express permission. This website also contains material copyrighted by 3rd parties. Administer thyroid hormone supplementation. Treatment with Class I or III antiarrhythmics (e.g., amiodarone, flecainide, propafenone, quinidine, disopyramide, dofetilide, sotalol) or drugs that are strong inhibitors of CYP3A (e.g., ketoconazole) must be stopped before starting MULTAQ, HOW SUPPLIED MULTAQ 400-mg tablets are provided as white film-coated tablets for oral administration, oblong-shaped, engraved with a double wave marking on one side and "4142" code on the other side in:Bottles of 60 tablets, NDC 0024-4142-60 Bottles of 180 tablets, NDC 0024-4142-18 Bottles of 500 tablets NDC 0024-4142-50 Box of 10 blisters (10 tablets per blister) NDC 0024-4142-10. In most of the cases, the method of administration is via peripheral infusion. Obtain baseline and periodic liver transaminases and discontinue or reduce dose if the increase exceeds three times normal, or doubles in a patient with an elevated baseline. lxEG@Ff j|h^^xklM&A{r:hY3ES$O~"s\B@CK*c#wOgrPhRML,rAWy\ijC 5t4cJh)#pY stNbS7Y< A local search option of this data can be found here. Amiodarone is used in the treatment of atrial fibrillation, although the FDA has not approved this indication. Amiodarone Dosage Guide + Max Dose, Adjustments 2010;11:5763. Add 3 mL of Cordarone I.V. of vials = level (ng/mL) x body weight (kg) divided by 100, Digitoxin: No. May follow with 0.125 to 0.25 mg IV q2-6h until 0.75 to 1.5 mg is given over 24hrs. Amiodarone and DEA cross the placenta and both appear in breast milk. Cordarone I.V. The initial rate of infusion should be monitored closely and should not exceed that prescribed in DOSAGE AND ADMINISTRATION. Although no dosage adjustment for patients with renal, hepatic, or cardiac abnormalities has been defined during chronic treatment with oral amiodarone, close clinical monitoring is prudent for elderly patients and those with severe left ventricular dysfunction. concentrations should not exceed 2 mg/mL unless a central venous catheter is used. FDA-approved for acute termination of A-flutter/A-fib (may be alternative to cardioversion): 1mg IV over 10min. concentrations greater than 3 mg/mL in D5W have been associated with a high incidence of peripheral vein phlebitis; however, concentrations of 2.5 mg/mL or less appear to be less irritating. ---------------------------------------Supplied: Injection, powder for reconstitution: Digibind: 38 mg. ========================= Dilution: Prescribed dose/ 50 ml NS. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Add 18 ml of Cordarone I.V. Hypotension should be treated initially by slowing the infusion; additional standard therapy may be needed, including the following: vasopressor drugs, positive inotropic agents, and volume expansion. <> For chronic toxicity: 6 vials; for infants and small children Intravenous to Oral Transition of Amiodarone (IOTA): Effect No significant association was found between various overlap durations and AF recurrence (odds ratio (OR) 1.00, 95% CI 1.00-1.01, P = 0.9). Typical amiodarone dosages in the ACLS setting are provided in Table 1.2,10 In patients who require long-term treatment, intravenous dosing should be switched to oral dosing. Small doses (infants/small children) may be administered using tuberculin syringe. CRCL 20-39 ml/min: Administer 125 mcg twice daily. After absorption, the drug undergoes extensive enterohepatic circulation. Patients who received intravenous amiodarone for less than one week should take 800 to 1,600 mg oral amiodarone per day. Abstract The use of amiodarone for postoperative atrial fibrillation (AF) is widespread; however, there is a paucity of data on the optimal duration of overlap when transitioning from intravenous (IV) to oral amiodarone. Cordarone I.V. [Loading: 10 to 15 mcg/kg IBW in divided doses (q4-8h) over 12-24hrs.] %PDF-1.7 The difficulty of using this drug safely and effectively itself poses a significant risk to patients. Add 18 mL of Cordarone I.V. Crcl 40-60 ml/min: Administer every 24 hours. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Adjust infusion rate as needed to maintain desired heart rate and/or blood pressure, up to 300 mcg/kg/minute. Infuse 100 mL over 10 minutes. Assistant Professor of Pharmacy Practice /Assistant Professor of Medicine, Schools of Pharmacy & Medicine, Loma Linda University, Loma Linda, California; Co-Director, Lipid Clinic, VA Loma Linda Healthcare System, Loma Linda, California. Supplied: 250 mg, 500 mg capsule. Intravenous
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